Saddest Anime Death

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Choose the saddest anime death. There are spoilers from:"Naruto/Naruto Shippuden, One Piece, Attack on Titan, Death Note, Your Lie in April, Gurren Lagann, Fullmetal Alchemist: Brotherhood, Hunter x Hunter, Code Geass: Lelouch of the Rebellion, Demon Slayer, Vinland Saga"